Carol Podlasek

FAQ About Carol Podlasek

• What is Carol Podlasek's address?

  Carol Podlasek is located at
  Chicago, Chicago, United States

• What is Carol Podlasek's job title?

  Carol Podlasek is a
  Major Professional Interest My research focuses on how neural innervation establishes and maintains tissue morphology, and how neural injury contributes to disease development. An ideal model we have been studying the last 20 years focuses on prostatectomy, diabetic and aging patients in which the cavernous nerve, which provides innervation to the penis, becomes injured with surgical insult (prostatectomy), or with development of peripheral neuropathy (diabetes and aging), resulting in erectile dysfunction (ED). ED affects ~ 50% of men aged 40 to 70 and has a high impact on men’s health and quality of life. Current treatments are ineffective in prostatectomy (16-82%) and diabetic (56-59%) patients in which there is significant cavernous nerve (CN) injury. With denervation the penis undergoes irreversible remodeling, including apoptosis of critical smooth muscle (up to 50%) and fibrosis, with increased collagen and a change in subtypes, making the corpora cavernosa unable to respond to normal neurotransmitter signals. In order to devise novel and effective ED therapies, damage to the CN must be mitigated, and smooth muscle apoptosis and collagen remodeling prevented. My research targets all three of these processes with development of novel nanoparticle based delivery of sonic hedgehog (SHH) protein in vivo to accelerate cavernous nerve regeneration and maintain corpora cavernosal morphology while the nerve regenerates, in order to re-establish erectile function. Society For Pelvic Research

• What industry does Carol Podlasek currently work in?

  Carol Podlasek currently works in the
  Society For Pelvic Research

• What is Carol Podlasek's area of expertise?

  Carol Podlasek specializes in
  Major Professional Interest My research focuses on how neural innervation establishes and maintains tissue morphology, and how neural injury contributes to disease development. An ideal model we have been studying the last 20 years focuses on prostatectomy, diabetic and aging patients in which the cavernous nerve, which provides innervation to the penis, becomes injured with surgical insult (prostatectomy), or with development of peripheral neuropathy (diabetes and aging), resulting in erectile dysfunction (ED). ED affects ~ 50% of men aged 40 to 70 and has a high impact on men’s health and quality of life. Current treatments are ineffective in prostatectomy (16-82%) and diabetic (56-59%) patients in which there is significant cavernous nerve (CN) injury. With denervation the penis undergoes irreversible remodeling, including apoptosis of critical smooth muscle (up to 50%) and fibrosis, with increased collagen and a change in subtypes, making the corpora cavernosa unable to respond to normal neurotransmitter signals. In order to devise novel and effective ED therapies, damage to the CN must be mitigated, and smooth muscle apoptosis and collagen remodeling prevented. My research targets all three of these processes with development of novel nanoparticle based delivery of sonic hedgehog (SHH) protein in vivo to accelerate cavernous nerve regeneration and maintain corpora cavernosal morphology while the nerve regenerates, in order to re-establish erectile function.

• Which languages does Carol Podlasek speak? 

  Carol Podlasek speaks the following languages:
  No languages available.

• Which industries has Carol Podlasek previously worked in?   

  Carol Podlasek has prior experience in the following industries:
  Northwestern University , Northwestern University , Northwestern University , Northwestern University , Us Epa

• What is Carol Podlasek’s work experience?  

  Carol Podlasek has the following professional experience:
  Society For Pelvic Research , Department Of Urology University Of Illinois At Chicago , Northwestern University , Northwestern University , Northwestern University , Northwestern University , Us Epa .

• How can I find Carol Podlasek on LinkedIn?  

  You can view Carol Podlasek’s
  LinkedIn profile at LinkedIn URL.

• What are Carol Podlasek’s work email addresses?  

  Carol Podlasek’s work email addresses are
  [email protected] .

• What company does Carol Podlasek work for?  

  Carol Podlasek works at
  Society For Pelvic Research