
Harriet Nilsson
I started my career as a musician (cellist). Due to scoliosis, I had to give up this profession,... | Greater Uppsala Metropolitan Area, Greater Uppsala Metropolitan Area, Sweden
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Harriet Nilsson’s Emails ha****@ki****.se
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Harriet Nilsson’s Location Greater Uppsala Metropolitan Area, Greater Uppsala Metropolitan Area, Sweden
Harriet Nilsson’s Expertise I started my career as a musician (cellist). Due to scoliosis, I had to give up this profession, but I was lucky to be able to change into the exciting field of life science and electron microscopy. From 20170601: Structural determination of the Bri2 BRICHOS domain Alzheimer’s disease (AD) is a fatal neurodegenerative disorder, where amyloid plaques, manly from the amyloid-β42 (Aβ42), accumulate in the brain. The Bri2 BRICHOS domain has a physiological role in delaying A40 and A42 fibril formation and toxicity in vitro and in vivo. The anti-amyloid chaperone activity of Bri2 BRICHOS makes it a promising treatment strategy for AD. The aim of the project is to obtain high resolution structural data from the Bri2 BRICHOS domain. Collaborators: Jan Johansson, Center for Alzheimer Research, KI; and the group of prof. Hans Hebert, Department of Biosciences and Nutrition, KI, and School of Technology and Health, KTH Royal Institute of Technology, Novum, Huddinge. Novel 3D electron density maps are recently obtained. Further structural studies via high resolution single particle and cryo electron microscopy techniques will be performed. 2010-20170531: Molecular structure, packing and release of gelforming mucins with relevance to Cystic fibrosis In many diseases, such as different inflammations in the airways and intestine, the expression of mucins is altered. In CF an extremely viscous fluid is built up. Understanding the N-terminal calcium and pH dependent mechanisms of packing and secretion of mucins may be helpful in designing novel therapeutics. Collaborators: Gunnar C. Hansson mucin biology group, University of Gothenburg, Sweden; the group of Hans Hebert, Karolinska Institutet (KI) and School of Technology and Health, Royal Institute of Technology, Huddinge, Sweden, Novel 3D electron density maps were recently obtained for all gel forming mucins.
Harriet Nilsson’s Current Industry Kungliga Tekniska Hogskolan
Harriet
Nilsson’s Prior Industry
University Of Gothenburg
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Karolinska Institutet
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Kungliga Tekniska Hogskolan
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Work Experience

Kungliga Tekniska Hogskolan
Researcher Cryo Electron Microscopy, Brichos Domains, Alzheimers Disease
Thu Jun 01 2017 00:00:00 GMT+0000 (Coordinated Universal Time) — Present
Karolinska Institutet
PhD, researcher, Electron Microscopy, Mucins
Mon Dec 01 2014 00:00:00 GMT+0000 (Coordinated Universal Time) — Present
University Of Gothenburg
PhD, Post doc, Reseracher, Electron Microscopy, Mucins
Fri Jan 01 2010 00:00:00 GMT+0000 (Coordinated Universal Time) — Sat Nov 01 2014 00:00:00 GMT+0000 (Coordinated Universal Time)