
James Roede
The focus of my research program is to investigate cellular mechanisms of toxicity of environmental chemicals and known... | Denver, Denver, United States
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James Roede’s Emails ja****@cu****.edu
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James Roede’s Location Denver, Denver, United States
James Roede’s Expertise The focus of my research program is to investigate cellular mechanisms of toxicity of environmental chemicals and known therapeutics. Specifically, my laboratory studies the impact that environmental chemicals, like the fungicide maneb, has on the initiation and progression of neurodegenerative diseases. Of great interest to the laboratory is Down syndrome (DS) and the mechanisms that render these individuals susceptible to developing a variety of comorbidities, like early onset Alzheimer’s disease, diabetes, leukemia, and cognitive dysfunction. We believe that proteostasis dysfunction is a major factor that contributes to these comorbidities observed DS as well as other neurodegenerative diseases. To study these conditions, we routinely utilize basic cell biology techniques, systems biology approaches, and in vitro, in vivo, and stem cell based models. Specialties: Oxidative stress, mechanistic toxicology, lipid peroxidation, reactive aldehydes, thiol containing antioxidant proteins, post-translational modifications, thiol-reactive metals, proteomics, metabolomics, iPS cell-based models
James Roede’s Current Industry University Of Colorado Anschutz Medical Campus
James
Roede’s Prior Industry
Mpi Research
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Emory University
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University Of Colorado Anschutz Medical Campus
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Toxicology Reports
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Work Experience

University Of Colorado Anschutz Medical Campus
Associate Professor
Mon Jun 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) — Present
Toxicology Reports
Associate Editor
Thu Jan 01 2015 00:00:00 GMT+0000 (Coordinated Universal Time) — Tue Aug 01 2017 00:00:00 GMT+0000 (Coordinated Universal Time)
University Of Colorado Anschutz Medical Campus
Assistant Professor
Thu Aug 01 2013 00:00:00 GMT+0000 (Coordinated Universal Time) — Mon Jun 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time)
Emory University
Postdoctoral Fellow
Wed Jul 01 2009 00:00:00 GMT+0000 (Coordinated Universal Time) — Mon Jul 01 2013 00:00:00 GMT+0000 (Coordinated Universal Time)
Mpi Research
Project Leader - Large Animal Toxicology
Tue Jan 01 2002 00:00:00 GMT+0000 (Coordinated Universal Time) — Tue Jun 01 2004 00:00:00 GMT+0000 (Coordinated Universal Time)
Mpi Research
Research Associate - Safety Pharmacology
Tue May 01 2001 00:00:00 GMT+0000 (Coordinated Universal Time) — Tue Jan 01 2002 00:00:00 GMT+0000 (Coordinated Universal Time)