
Madaiah Puttaraju
Scientist with extensive experience in Gene Therapy, RNA Therapy and Molecular Biology in both biotech industry and academic... | Germantown, Maryland, United States
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Madaiah Puttaraju’s Location Germantown, Maryland, United States
Madaiah Puttaraju’s Expertise Scientist with extensive experience in Gene Therapy, RNA Therapy and Molecular Biology in both biotech industry and academic settings. I was a key player in the development of the “Spliceosome Mediated RNA Trans-splicing” (SMaRT) technology and played a key role in the proof-of-concept demonstration to pre-clinical studies in squirrel monkeys. I have extensive hands-on experience in product development, optimization and proof-of-concept demonstration of SMaRT technology for various gene therapy applications including - • Cancer (eg., human papillomavirus [HPV], suicide therapy) • Correction of genetic defects and restore phenotypic function (egs., cystic fibrosis, hemophilia, severe combined immune deficiency [SCID]) • Cardiovascular diseases (HDL deficiency, apoA-I, LDL receptor) • Skin disease (epidermolysis bullosa) • Diagnostic application - real-time molecular imaging of gene expression in live cells Broad research knowledge in preclinical work designing and testing of lead biologics for efficacy and safety in small and large animal models, tox and biodistribution studies, various delivery systems such as plasmids, minicircles and viral-based vectors (AAV, Lenti). Experience in writing IACUC bio-safety protocols and BSL3 working condition experience. Familiar with SBIR and CRADA grant mechanism between NIH and Biotech industry. Excellent track record of publications (Nat Biotech, PNAS, Mol Ther, J Nucl Med), authored several patents and publicly presented data from Scientific meetings to Investor road shows. I have supervised up to 7 staff members including PhD's; written and reviewed SOPs and Training Records for junior employees. I have experience in project management, interaction with higher management on the status of progress of the project, timelines etc.
Madaiah Puttaraju’s Current Industry Nci
Madaiah
Puttaraju’s Prior Industry
Intronn
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Virxsys
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Work Experience

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Research Fellow
Sat Sep 01 2012 00:00:00 GMT+0000 (Coordinated Universal Time) — Present
Virxsys
Senior Scientist, SMaRT Development Group
Sat Sep 01 2007 00:00:00 GMT+0000 (Coordinated Universal Time) — Thu Mar 01 2012 00:00:00 GMT+0000 (Coordinated Universal Time)
Intronn
Scientist
Sat Jun 01 1996 00:00:00 GMT+0000 (Coordinated Universal Time) — Sat Sep 01 2007 00:00:00 GMT+0000 (Coordinated Universal Time)