Mark Tan mark.tan@marquette.edu & | - Developing a gel system to identify the phosphorylation of myosin binding protein-C (MyBPC) and myosin light chain 2 (MLC2) in cardiac and skeletal muscle fibers. - Both of these proteins are phosphorylated with activity and we suspect they are important in muscle fatigue and age induced changes in function in both skeletal and heart cells. - Further developing a mechanism to phosphorylate myosin light chain 2 to obtain varying levels of phosphorylation on a individual muscle fiber. Responsible for making, running, and silver-staining gels. - Assisted in assessing the functional and mechanical properties of single cardiac cells (myocyte heart cells) and their adaptation to exercise training. Cells were mounted between a force transducer and motor arm and physiological parameters such as force and velocity were measured. Assessed differences between control and trained hearts, such as alterations due to exercise training, and elucidate the cellular causes of fatigue - Course Contributor to BIOL 8957-102: Seminar in Physiology: Heart Disease Molecular Cell Studies Seminar course in Cardiac Muscle with an emphasis on disease alterations for Biological Sciences majors, Master of Science, or Doctor of Philosophy (Ph.D) candidates. - Conducted statistical and background investigations which examined if any baseline characteristics existed that can predict a poor procedural response to BAV - Reviewed the medical records of seventy-four patients that underwent BAV using PowerChart and EPIC patient databases to develop risk models based on INTERMACS and euroSCORE patient data - Took a leadership role in statistical facets of the project, requiring meticulous communication with physicians and a unique opportunity to apply clinical research to the bedside - Manuscript and abstract writing contribution PUBLICATIONS/ABSTRACTS Cheung M, Tempelhof M, Tan M, Beohar N. The Baseline Characteristics Predictive of a Poor Procedural Response to Balloon Aortic Valvuloplasty Among a Cohort of High-Surgical Risk Patients with Aortic Stenosis. AHA Journal Circulation: Cardiovascular Quality and Outcomes. Volume 4, Issue 6 Supplement. November 2011. POSTER PRESENTATIONS Cheung M, Tempelhof M, Tan M, Beohar N. The Baseline Characteristics Predictive of a Poor Procedural Response to Balloon Aortic Valvuloplasty Among a Cohort of High-Surgical Risk Patients with Aortic Stenosis. 1. International Academy of Cardiology: 16th World Congress on Heart Disease Annual Scientific Sessions 2011; Vancouver, B.C., Canada 2. American Heart Association: Quality of Care and Outcomes Research 2011 Scientific Sessions; Washington, D.C. 3. Northwestern University Feinberg School of Medicine: Seventh Annual Lewis Landsberg Research Day; Chicago, IL.

Mark Tan

- Developing a gel system to identify the phosphorylation of myosin binding protein-C (MyBPC) and myosin light chain...

Chicago, Chicago, United States

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Mark Tan’s Location Chicago, Chicago, United States

Mark Tan’s Expertise - Developing a gel system to identify the phosphorylation of myosin binding protein-C (MyBPC) and myosin light chain 2 (MLC2) in cardiac and skeletal muscle fibers. - Both of these proteins are phosphorylated with activity and we suspect they are important in muscle fatigue and age induced changes in function in both skeletal and heart cells. - Further developing a mechanism to phosphorylate myosin light chain 2 to obtain varying levels of phosphorylation on a individual muscle fiber. Responsible for making, running, and silver-staining gels. - Assisted in assessing the functional and mechanical properties of single cardiac cells (myocyte heart cells) and their adaptation to exercise training. Cells were mounted between a force transducer and motor arm and physiological parameters such as force and velocity were measured. Assessed differences between control and trained hearts, such as alterations due to exercise training, and elucidate the cellular causes of fatigue - Course Contributor to BIOL 8957-102: Seminar in Physiology: Heart Disease Molecular Cell Studies Seminar course in Cardiac Muscle with an emphasis on disease alterations for Biological Sciences majors, Master of Science, or Doctor of Philosophy (Ph.D) candidates. - Conducted statistical and background investigations which examined if any baseline characteristics existed that can predict a poor procedural response to BAV - Reviewed the medical records of seventy-four patients that underwent BAV using PowerChart and EPIC patient databases to develop risk models based on INTERMACS and euroSCORE patient data - Took a leadership role in statistical facets of the project, requiring meticulous communication with physicians and a unique opportunity to apply clinical research to the bedside - Manuscript and abstract writing contribution PUBLICATIONS/ABSTRACTS Cheung M, Tempelhof M, Tan M, Beohar N. The Baseline Characteristics Predictive of a Poor Procedural Response to Balloon Aortic Valvuloplasty Among a Cohort of High-Surgical Risk Patients with Aortic Stenosis. AHA Journal Circulation: Cardiovascular Quality and Outcomes. Volume 4, Issue 6 Supplement. November 2011. POSTER PRESENTATIONS Cheung M, Tempelhof M, Tan M, Beohar N. The Baseline Characteristics Predictive of a Poor Procedural Response to Balloon Aortic Valvuloplasty Among a Cohort of High-Surgical Risk Patients with Aortic Stenosis. 1. International Academy of Cardiology: 16th World Congress on Heart Disease Annual Scientific Sessions 2011; Vancouver, B.C., Canada 2. American Heart Association: Quality of Care and Outcomes Research 2011 Scientific Sessions; Washington, D.C. 3. Northwestern University Feinberg School of Medicine: Seventh Annual Lewis Landsberg Research Day; Chicago, IL.

Mark Tan’s Current Industry Marquette University

Mark Tan’s Prior Industry
Northwestern Memorial Hospital | Marquette University

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Marquette University

Exercise Physiology Researcher

Sun Jan 01 2012 00:00:00 GMT+0000 (Coordinated Universal Time) — Tue Jan 01 2013 00:00:00 GMT+0000 (Coordinated Universal Time)

Northwestern Memorial Hospital

Cardiovascular Disease Researcher

Fri Jan 01 2010 00:00:00 GMT+0000 (Coordinated Universal Time) — Sun Jan 01 2012 00:00:00 GMT+0000 (Coordinated Universal Time)

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Mark Tan is located at
Chicago, Chicago, United States

Mark Tan is a
- Developing a gel system to identify the phosphorylation of myosin binding protein-C (MyBPC) and myosin light chain 2 (MLC2) in cardiac and skeletal muscle fibers. - Both of these proteins are phosphorylated with activity and we suspect they are important in muscle fatigue and age induced changes in function in both skeletal and heart cells. - Further developing a mechanism to phosphorylate myosin light chain 2 to obtain varying levels of phosphorylation on a individual muscle fiber. Responsible for making, running, and silver-staining gels. - Assisted in assessing the functional and mechanical properties of single cardiac cells (myocyte heart cells) and their adaptation to exercise training. Cells were mounted between a force transducer and motor arm and physiological parameters such as force and velocity were measured. Assessed differences between control and trained hearts, such as alterations due to exercise training, and elucidate the cellular causes of fatigue - Course Contributor to BIOL 8957-102: Seminar in Physiology: Heart Disease Molecular Cell Studies Seminar course in Cardiac Muscle with an emphasis on disease alterations for Biological Sciences majors, Master of Science, or Doctor of Philosophy (Ph.D) candidates. - Conducted statistical and background investigations which examined if any baseline characteristics existed that can predict a poor procedural response to BAV - Reviewed the medical records of seventy-four patients that underwent BAV using PowerChart and EPIC patient databases to develop risk models based on INTERMACS and euroSCORE patient data - Took a leadership role in statistical facets of the project, requiring meticulous communication with physicians and a unique opportunity to apply clinical research to the bedside - Manuscript and abstract writing contribution PUBLICATIONS/ABSTRACTS Cheung M, Tempelhof M, Tan M, Beohar N. The Baseline Characteristics Predictive of a Poor Procedural Response to Balloon Aortic Valvuloplasty Among a Cohort of High-Surgical Risk Patients with Aortic Stenosis. AHA Journal Circulation: Cardiovascular Quality and Outcomes. Volume 4, Issue 6 Supplement. November 2011. POSTER PRESENTATIONS Cheung M, Tempelhof M, Tan M, Beohar N. The Baseline Characteristics Predictive of a Poor Procedural Response to Balloon Aortic Valvuloplasty Among a Cohort of High-Surgical Risk Patients with Aortic Stenosis. 1. International Academy of Cardiology: 16th World Congress on Heart Disease Annual Scientific Sessions 2011; Vancouver, B.C., Canada 2. American Heart Association: Quality of Care and Outcomes Research 2011 Scientific Sessions; Washington, D.C. 3. Northwestern University Feinberg School of Medicine: Seventh Annual Lewis Landsberg Research Day; Chicago, IL. Marquette University

Mark Tan currently works in the
Marquette University

Mark Tan specializes in
- Developing a gel system to identify the phosphorylation of myosin binding protein-C (MyBPC) and myosin light chain 2 (MLC2) in cardiac and skeletal muscle fibers. - Both of these proteins are phosphorylated with activity and we suspect they are important in muscle fatigue and age induced changes in function in both skeletal and heart cells. - Further developing a mechanism to phosphorylate myosin light chain 2 to obtain varying levels of phosphorylation on a individual muscle fiber. Responsible for making, running, and silver-staining gels. - Assisted in assessing the functional and mechanical properties of single cardiac cells (myocyte heart cells) and their adaptation to exercise training. Cells were mounted between a force transducer and motor arm and physiological parameters such as force and velocity were measured. Assessed differences between control and trained hearts, such as alterations due to exercise training, and elucidate the cellular causes of fatigue - Course Contributor to BIOL 8957-102: Seminar in Physiology: Heart Disease Molecular Cell Studies Seminar course in Cardiac Muscle with an emphasis on disease alterations for Biological Sciences majors, Master of Science, or Doctor of Philosophy (Ph.D) candidates. - Conducted statistical and background investigations which examined if any baseline characteristics existed that can predict a poor procedural response to BAV - Reviewed the medical records of seventy-four patients that underwent BAV using PowerChart and EPIC patient databases to develop risk models based on INTERMACS and euroSCORE patient data - Took a leadership role in statistical facets of the project, requiring meticulous communication with physicians and a unique opportunity to apply clinical research to the bedside - Manuscript and abstract writing contribution PUBLICATIONS/ABSTRACTS Cheung M, Tempelhof M, Tan M, Beohar N. The Baseline Characteristics Predictive of a Poor Procedural Response to Balloon Aortic Valvuloplasty Among a Cohort of High-Surgical Risk Patients with Aortic Stenosis. AHA Journal Circulation: Cardiovascular Quality and Outcomes. Volume 4, Issue 6 Supplement. November 2011. POSTER PRESENTATIONS Cheung M, Tempelhof M, Tan M, Beohar N. The Baseline Characteristics Predictive of a Poor Procedural Response to Balloon Aortic Valvuloplasty Among a Cohort of High-Surgical Risk Patients with Aortic Stenosis. 1. International Academy of Cardiology: 16th World Congress on Heart Disease Annual Scientific Sessions 2011; Vancouver, B.C., Canada 2. American Heart Association: Quality of Care and Outcomes Research 2011 Scientific Sessions; Washington, D.C. 3. Northwestern University Feinberg School of Medicine: Seventh Annual Lewis Landsberg Research Day; Chicago, IL.