Mike Eby

FAQ About Mike Eby

• What is Mike Eby's address?

  Mike Eby is located at
  South San Francisco, California, United States

• What is Mike Eby's job title?

  Mike Eby is a
  Bioassay expert with several GxP bioassays on control systems at Genentech (see Poster and Patent sections). Currently working on target selection and validation of immune-related genes from 23andMe's GWAS/PheWAS data for early-stage drug development with an emphasis on making QC-ready bioassays and supporting orthogonal primary bioassays to for drug candidate selection. I most enjoy cell line engineering to generate QC-ready bioassays as early as possible not only to make better drugs for patients, but also to save time and money in development. Using crenezumab as an example of why earlier is better, I had been tasked with generating the regulatory-required bioassay for crenezumab while in Ph3 (see Patent section). With my assay, we discovered issues with new higher-yield lots of the late-stage drug that were NOT seen in the characterized/validated binding assays used through Ph2 -- Delaying generating the characterized/valdiated bioassay until Ph3 proved to be expensive and a waste of resources. ELISA assays are generally faster to validate, but they cannot address important relevant functional information (e.g. interaction w/ the plasma membrane, co-receptor interaction(s), hyperpotency of HMWS/LMWS impurities in DS/DP, etc). Had we had the assay in place in Ph1/2, we could have made a proper higher-yield biosimilar of our own drug... A well-made QC-ready reporter cell line is easy to use, captures a major mechanism of action and, ideally, should be well characterized in early stage research to enable consistency through commercialization. If possible, a well-characterized orthogonal primary cell-based assay should also be in place before Ph1. This is what I do for my inflammation and immunology projects at 23andMe. 23andme

• What industry does Mike Eby currently work in?

  Mike Eby currently works in the
  23andme

• What is Mike Eby's area of expertise?

  Mike Eby specializes in
  Bioassay expert with several GxP bioassays on control systems at Genentech (see Poster and Patent sections). Currently working on target selection and validation of immune-related genes from 23andMe's GWAS/PheWAS data for early-stage drug development with an emphasis on making QC-ready bioassays and supporting orthogonal primary bioassays to for drug candidate selection. I most enjoy cell line engineering to generate QC-ready bioassays as early as possible not only to make better drugs for patients, but also to save time and money in development. Using crenezumab as an example of why earlier is better, I had been tasked with generating the regulatory-required bioassay for crenezumab while in Ph3 (see Patent section). With my assay, we discovered issues with new higher-yield lots of the late-stage drug that were NOT seen in the characterized/validated binding assays used through Ph2 -- Delaying generating the characterized/valdiated bioassay until Ph3 proved to be expensive and a waste of resources. ELISA assays are generally faster to validate, but they cannot address important relevant functional information (e.g. interaction w/ the plasma membrane, co-receptor interaction(s), hyperpotency of HMWS/LMWS impurities in DS/DP, etc). Had we had the assay in place in Ph1/2, we could have made a proper higher-yield biosimilar of our own drug... A well-made QC-ready reporter cell line is easy to use, captures a major mechanism of action and, ideally, should be well characterized in early stage research to enable consistency through commercialization. If possible, a well-characterized orthogonal primary cell-based assay should also be in place before Ph1. This is what I do for my inflammation and immunology projects at 23andMe.

• Which languages does Mike Eby speak? 

  Mike Eby speaks the following languages:
  No languages available.

• Which industries has Mike Eby previously worked in?   

  Mike Eby has prior experience in the following industries:
  23andme , 23andme , 23andme , Genentech , Genentech , Ut Southwestern Medical Center , University Of Washington

• What is Mike Eby’s work experience?  

  Mike Eby has the following professional experience:
  23andme , 23andme , 23andme , 23andme , Genentech , Genentech , Ut Southwestern Medical Center , University Of Washington .

• How can I find Mike Eby on LinkedIn?  

  You can view Mike Eby’s
  LinkedIn profile at LinkedIn URL.

• What are Mike Eby’s work email addresses?  

  Mike Eby’s work email addresses are
  [email protected].

• What company does Mike Eby work for?  

  Mike Eby works at
  23andme