
Skirmantas Kriaucionis
Principal Investigator working on the epigenetic mechanisms in cancer and normal neuronal cells. Broad scientific interests: a) innovative... | Oxford, Oxford, United Kingdom
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Skirmantas Kriaucionis’s Location Oxford, Oxford, United Kingdom
Skirmantas Kriaucionis’s Expertise Principal Investigator working on the epigenetic mechanisms in cancer and normal neuronal cells. Broad scientific interests: a) innovative ways to fund science to achieve the best impact; b) quality and reproducibility of science. Current group is investigating three directions - 1) How epigenetic DNA modifications impact on transcription? Are similar mechanisms employed in cancer and normal cells? 2) How DNA modifications affects mutability of the DNA? 3) How nucleotide metabolism is regulated for accurate, DNA modification free replication of DNA? The key achievements include identification of new MeCP2 isoform and characterisation of gene expression abnormalities in mouse model of Rett Syndrome (phD, University of Edinburgh, under supervision of Prof. Adrian Bird). Pioneering cell type specific analysis of neuronal chromatin resulted in identification of new DNA modification - 5-hydroxymethylcytosine (post-doctoral work, Rockefeller University, under supervision of Prof. Nathaniel Heintz). While leading independent group (University of Oxford), the investigator defined the mechanism in nucleotide metabolism enabling "clean" pool of nucleotides for DNA synthesis; proposed a new mechanism for one of the dominant mutational processes in cancer.
Skirmantas Kriaucionis’s Current Industry University Of Oxford
Skirmantas
Kriaucionis’s Prior Industry
The University Of Edinburgh
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Rockefeller University
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University Of Oxford
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Work Experience

University Of Oxford
Associate Professor
Fri Jul 01 2016 00:00:00 GMT+0000 (Coordinated Universal Time) — Present
University Of Oxford
Principal Investigator
Fri Oct 01 2010 00:00:00 GMT+0000 (Coordinated Universal Time) — Present
Rockefeller University
Pos-Doctoral Associate
Mon May 01 2006 00:00:00 GMT+0000 (Coordinated Universal Time) — Fri Oct 01 2010 00:00:00 GMT+0000 (Coordinated Universal Time)
The University Of Edinburgh
Post-Doctoral Associate
Sat Jan 01 2005 00:00:00 GMT+0000 (Coordinated Universal Time) — Mon May 01 2006 00:00:00 GMT+0000 (Coordinated Universal Time)